# Selank publications

> Selank publications | Easy Peptide — The Easy Peptide reading list: Selank studies of rat BDNF and GABA-related gene expression, human plasma enzymes, anxiety and immune measurements.

The rat hippocampus paper is the starting point. The patient report and the laboratory assays take the question in different directions.

## Hippocampal BDNF

[Intranasal Selank and BDNF expression in rat hippocampus](https://pubmed.ncbi.nlm.nih.gov/18841804/) supplies the molecular starting point. The [clinical report in generalized anxiety disorder](https://pubmed.ncbi.nlm.nih.gov/18454096/) describes anxiety and tolerability outcomes in patients. Preserved cognition is the question that joins them here. The measured outcomes remain different.

## Cortex and plasma experiments

The [rat GABA-related gene-expression experiment](https://pubmed.ncbi.nlm.nih.gov/26924987/), the [human-plasma enzyme assay](https://pubmed.ncbi.nlm.nih.gov/11550013/) and the [Selank–Semax serum comparison](https://pubmed.ncbi.nlm.nih.gov/11443939/) pursue different biological processes. The separate [immune study in patients with anxiety-asthenic disorders](https://pubmed.ncbi.nlm.nih.gov/18577961/) makes the biological picture broader still.

Full publication details follow. The publications below give this question its actual starting points.

## References

[1] Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo https://pubmed.ncbi.nlm.nih.gov/18841804/
[2] Efficacy and possible mechanisms of action of a new peptide anxiolytic medication (selank) in the therapy of generalized anxiety disorders and neurasthenia https://pubmed.ncbi.nlm.nih.gov/18454096/
[3] Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission https://pubmed.ncbi.nlm.nih.gov/26924987/
[4] The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity https://pubmed.ncbi.nlm.nih.gov/11550013/
[5] Immunomodulatory effects of selank in patients with anxiety-asthenic disorders https://pubmed.ncbi.nlm.nih.gov/18577961/
[6] Semax and selank inhibit the enkephalin-degrading enzymes from human serum https://pubmed.ncbi.nlm.nih.gov/11443939/

---

At Easy Peptide I follow the uneasy meeting of calm and cognition in published research; these essays offer no medical advice.